In my production environment, there is one exchange 2016 mailbox server and MAPI already enabled on it. Most of users have Microsoft office 2010 and some has office 2016. Now all of Microsoft office 2010 users don't have any issue on outlook connectivity to exchange but outlook 2016 users experiencing with MAPI/HTTP connectivity issue to exchange.
I checked following MAPI test command on my exchange server and result is success.
Test-OutlookConnectivity -RunFromServerId ContosoMail -ProbeIdentity OutlookMapiHttpSelfTestProbe
and I checked connection status of outlook 2016.